Uryuu Kamihate faced challenges early in his life, but he aimed to put them behind him by pursuing his dream of attending medical school. However, when he moved into his new foster home, which happened to be a working shrine, his peaceful study environment was disrupted. To his surprise, he discovered that he would not only be sharing his home with three vibrant and energetic Amagami sisters, but also be required to marry one of them and assume responsibility for managing the temple.