In the near future, Japan develops an armored suit called Infinite Stratos (IS) for outer space exploration. However, it was later used as a military weapon until it became a new sport. The drawback of the IS is that only females can pilot it, which was believed to be true until Orimura Ichika came along. As the younger brother of famous pilot Orimura Chifuyu, who represented Japan and went undefeated in her professional career, Ichika is the only male in the world capable of piloting an IS. He enrolls at the IS Academy where all students are female except for him. His teacher is his sister Chifiyu, and he receives a lot of attention from the girls around him who are competing to win his affection. With so much flirting going on, Ichika barely has time to master using his IS.