Youkai Academy appears to be an ordinary boarding school where students study regular subjects like literature, gym, foreign language, and mathematics. However, there is one crucial rule at this institution - any human found on the premises must be executed immediately. Tsukune Aono, a teenager with poor grades, is enrolled in Youkai Academy by his parents as a last resort for his education. As he explores this new world, Tsukune encounters Moka Akashiya, the most attractive girl on campus. Unaware that she's a vampire, he develops feelings for her and decides to remain in the dangerous realm to pursue their relationship further. Rosario to Vampire is a supernatural school comedy series that follows Tsukunes romantic adventures with an array of beautiful yet perilous creatures.
The source material’s popularity has also led to the creation of drama CDs, visual novels, internet radio shows, and a novel adaption.