Working as a voice actress in the gaming industry may not be so daunting if you are not Kanna Aoyagi. On her 16th birthday, her older sister Yayoi pressured Kanna into doing voice work for Blue March, a company that specializes in eroge or adult games with explicit sexual content. Despite being innocent and naive, Kanna is determined to succeed at this job despite having no prior experience in the field. However, as she immerses herself in researching eroge, utilizing her imagination, and receiving guidance from her colleagues, Kanna begins to feel more confident about her new profession.
North American distributor Media Blasters offered replacement copies of the Koe de Oshigoto! DVDs due to an issue that caused the anime to loop back to the menu. The distributor had originally planned to have the anime officially dubbed, but later cancelled these plans. The release of the second episode DVD was postponed twice, coming out over a year after the first.