Yayoi is an accomplished biology expert who was hired onto the research team due to her exceptional skills. To accommodate her on the team, all members were female. As a college student, Yayoi struggled with a severe fear of men that stemmed from witnessing her parents having sex. This fear caused panic attacks whenever she encountered men, despite her deep desire for intimacy.
Yayoi became intrigued by her classmate's intimate relationship with one of their tutors, Sorata Muon. However, when a valuable sample was targeted for theft by Mouse, Yayoi found herself trapped in a lab fire triggered by one of her panic attacks. It was Sorata, who revealed himself as Mouse, who rescued her and helped her overcome her fear.
Now, Yayoi is one of Sorata's most devoted servants, constantly trying to create potions to enhance his sexual energy. She has expressed a strong desire for him to walk her around naked in public like a dog and have sex in public.