Shisui Uchiha was known as "Shisui of the Body Flicker" due to his exceptional abilities within the Uchiha clan. He and Itachi Uchiha were close friends, with Itachi considering him an older brother. Tragically, Shisui's life ended in what appeared to be a suicide, but it was later discovered that he had been tasked with monitoring Itachi by the Konoha Military Police. This revelation led to Itachi admitting to Sasuke Uchiha that he murdered Shisui in order to obtain the Mangekyou Sharingan and forge his handwriting on the suicide note with the help of the Sharingan.
Shisui obtained the Mangekyou Sharingan and a technique called Kotoamatsukami, which he intended to use to stop the Uchiha Coup d'Etat against Konohagakure. However, Danzo stole one of his eyes, forcing him to give his other eye to Itachi in order to protect the village. Ultimately, Shisui sacrificed himself by jumping off a cliff and dying, only to be found on the river later by the Uchiha military policemen. His eye proved instrumental in helping Itachi break free from Kabuto's Reanimation control.