Izuna Uchiha was younger brother of Madara Uchiha and lived about 70 years before the start of Naruto series. He stood at the top of the Uchiha clan with his brother and obtained one of the first Mangekyu Sharingan. However, due to Madara's use of it, he went blind. To help him regain sight, Izuna sacrificed his own eyes so that Madara could obtain a new, permanent Mangekyu.