Dr. Seishirou of Tokyo Babylon is a compassionate animal doctor who often jokes with Hokuto and Subaru about their potential union, although he quickly dismisses the idea as Subaru becomes flustered with embarrassment.
Seishirou is actually the Sakurazukamori (powerful assasin onmyouji), or the "Sakura Assassin" whose signature is cherry blossoms and the symbol of an inverted pentagram. He made a bet with Subaru long ago, which entails the climax of the series.
Seishirou is one of the Dragons of Earth, where he reveales his true self as a cold-hearted assassin who killed Subarus twin sister Hokuto. In their final battle at Rainbow Bridge, Seishirou arranges for Subaru to kill him realizing who really won the bet.