Cross Academy is an exclusive boarding school that separates its students into two classes: Day Class and Night Class. Yuuki Cross and Zero Kiryuu are prefects who attempt to maintain order between the classes as they rotate in the evenings. While the Night Class consists of beautiful elites, it can be challenging for Yuuki and Zero to keep them under control due to their vampire nature. As guardians, they protect the secrets of the Night Class and ensure the safety of the Day Class students who are unaware of their nocturnal counterparts.
Yuuki takes her role as the adopted daughter of the academy's chairman seriously and is energetic in her duties. This allows her to interact with her crush, Kaname Kuran, who is the president of the Night Students' dormitory. In contrast, Zero has a deep-seated hatred for vampires and may resort to killing at times. The coexistence of humans and vampires within Cross Academy remains uncertain as time progresses.
Vampire Knight was published in English by VIZ Media under the Shojo Beat imprint from January 2, 2007 to October 14, 2014. Two boxed sets were released: one includes the first 10 volumes of the manga, a planner, and a case and was released on November 16, 2010, while the other set includes the last 9 volumes released on November 4, 2014. It also had an official fanbook which was released in English by VIZ Media on October 19, 2010. The series was also published in Spanish as El Caballero Vampiro by Panini Comics from May 2008 to November 2014.The manga also received multiple drama CD adaptations, three novel adaptations, a fanbook (2008), a Japanese dating simulator titled Vampire Knight DS (2009), and a live action musical adaptation shown from January 21 to January 25, 2015.