Sotsugyo M centers around five distinct male pupils at Seiryuu Private Senior High School - Mikimaro Shimura, who values friendship above all else; Syo Nakamoto, a highly intelligent student learning to appreciate others; Togo Arai, the school's notorious playboy and troublemaker; Yuusuke Katou, an energetic student with feelings for his teacher; and Shimon Takagi, the new transfer student known for being wealthy and well-behaved. As they navigate their differences, these students learn to support one another, gradually revealing more about themselves and forming deeper connections.