Hayase Nagatoro is a high school student who enjoys spending her free time bullying her senpai. When she and her friends discover his artwork, they find pleasure in mercilessly teasing him. Despite this, Nagatoro remains determined to continue her cruel behavior towards Senpai, visiting him daily to force him into doing things that interest her at the moment, even if it makes him uncomfortable. Initially intimidated by and slightly aroused by Nagatoros presence, Senpai is drawn into her antics as she uses his interests, hobbies, appearance, and personality against him for entertainment purposes. Over time, Senpai comes to realize that he does not dislike Nagatoros company, leading the two of them to develop an uneasy friendship in which one tolerates the other's behavior.
Ijiranaide, Nagatoro-san has been published in English as Dont Toy With Me, Miss Nagatoro by Vertical Inc. since November 19, 2019.