The story revolves around Niko Kanzaki's experiences at St. Lunatic School, a prestigious institution known for its semi-demonic atmosphere. Initially attending due to her brother's employment there, she quickly discovers the eerie secret of the school during her night classes, which are overrun with demons. Through her studies, Niko learns about the differences between humans and demons. However, her understanding is further expanded by the enigmatic Ren, who reveals that their two races may not be as different as she once thought.
Yoru ni mo Makezu! was first published in English as St. Lunatic High School by Tokyopop from August 7 to December 11, 2007. VIZ Media later took over the license, and published the title digitally under the VIZ Select imprint from August 26 to September 30, 2014.