Since Kotoko Aihara entered high school, she had always desired to be in the same class as Naoki Irie. However, there was a problem; Irie was the smartest student in school while Kotoko was one of the dumbest. Despite this, her wish remained unfulfilled even after three years in high school. One day, her home was destroyed and she had no other choice but to seek refuge at Irie's house. Now that they live close to each other, will their relationship deepen or remain stagnant? In Volume 1: "Boku ga Naku," Kotoko expresses her feelings of loneliness and isolation, while in Volume 20: "Pink no Yuki ga Futtara," she struggles with self-doubt and low self-esteem.
Due to authors sudden death, Itazura na Kiss manga remains unfinished, but the 2008 anime adaptation portrays the authors planned ending found in her notes. Tada Kaoru had an accident while she was moving homes with her son and husband, and passed away around two and half weeks later.The series has been published in English by Digital Manga Publishing since November 4, 2009. Media Do International/Mz Planning has been digitally publishing the series as itazurana Kiss since November 7, 2017.