A young boy named Yuuichirou loses his parents and is taken in by the Hyakuya Orphanage. Despite struggling to bond with his new "family," he soon faces a greater challenge when a pandemic kills all above the age of 13, allowing vampires to rise from their slumber and enslave humanity. Four years later, Yuuichirou and his family have adapted to life under vampire rule, but Yuuichirou still dreams of killing all vampires and ending their oppression. His aspirations often put him at odds with Mikaela Hyakuya, who believes in using cunning and intelligence to survive. With inside knowledge from high-ranking vampires, Mikaela plans an escape, but the group is intercepted by Ferid Bathory, who massacres them except for Yuuichirou. He escapes to the surface and is discovered by the Moon Demon Company, a military unit that hunts down vampires. Yuuichirou accepts their invitation to join, finally receiving an opportunity to achieve his goals and avenge his family.
Owari no Seraph has been published in English as Seraph of the End: Vampire Reign by VIZ Media under the Shonen Jump Advanced imprint since June 3, 2014. The series has also been serialized in VIZ Medias digital Weekly Shonen Jump since October 7, 2013. It has also been published in Italian by Panini Comics since November 5, 2015; in Spanish by Norma Editorial since May 5, 2016; in Polish by Waneko since August 25, 2016; and in Brazilian Portuguese by Panini Comics since May 10, 2017.