In 1979, while studying at Keio University, he made his debut with Crusher Joe. At around the same time, he joined Studio Nue (スタジオぬえ) as an animator. His work has been featured in various manga anthology series such as Petit Apple Pie. Hosono is also the creator of Gallery Fake and Tarō, for which he received the Shogakukan Manga Award for general manga in 1996.