Takashi Natsume possesses unique abilities that allow him to see supernatural beings known as youkai. He conceals these abilities from his loved ones to safeguard their peaceful lives. Despite this, Natsume remains kind towards benevolent youkai and returns their names using the Book of Friends he inherited from his grandmother. Meanwhile, the Matoba exorcist clan seeks to recruit Natsume due to his exceptional gift. However, Natsume declines their invitation because not all exorcists practice reasonable methods like his friend Shuuichi Natori. Unsatisfied with Natsume's response, Seiji Matoba coerces him into attending a grand gathering of powerful exorcist families. At this event, Natsume encounters dangerous individuals and youkai alike. Nevertheless, he persists in opposing the harsh tactics of exorcists and believes in attaining peace between both worlds.
Natsume Yuujinchou Go was released on Blu-ray and DVD in five volumes from December 21, 2016 to April 26, 2017.