Kurisu is a research member at Victor Qondria University's Brain Research Program. She is around the age of third-year high schoolers but skipped a grade in America due to its educational system. Despite this, she has gained recognition for her thesis papers and is known in America. Her strong personality was developed as a result of being envied by those around her after skipping a grade. Kurisu maintains a stern expression to show no weakness to others but is very curious when building interest. She often holds unconventional views, such as prioritizing experiment data over subject privacy. Rintarou frequently teases her about her "Mad Scientist" persona, although she does not agree with this assessment personally. Kurisu is a tsundere and has been given nicknames like "Christina" (クリスティーナ) and "Assistant" (助手) by Rintarou.
" In the side story "The Far Valhalla," which explores Kurisu's, Okabe's, and Daru's fate after being captured by SERN, it's revealed that Okabe devised a plan to escape from SERN's headquarter in France, but as SERN learned that it would rule the world in the future, it let Okabe and Daru go in order to complete the cycle of fate. Kurisu gave up and stayed behind, but still believed that Okabe would be able to overcome fate. In 2034, she completed the time machine and was executed by SERN.
In the future of the Alpha world line where SERN rules, Makise worked for them. She made major contributions to the completion of SERNs time machine a
In the future of the Alpha Attractor Field where SERN rules, Makise works for them. She made major contributions to the completion of SERN's time machine and was praised as "Mother of Time Machine.
Because of her talent, she would always outsmart her own father, causing the two to come to bad terms.
Kurisu's allegiance with SERN in the future is the reason Suzuha, a member of the resistance against SERN's rule in 2036, is initially distrustful of her. However, Suzuha's opinion changes after she learns more about Kurisu's nature.Kurisu and her father are not on the best terms. When she was little, her father's lectures would fascinate her so much that she would read up on them herself. It was not long before she started getting into the science field.
Kurisu develops feelings toward Okabe.