In the series, we meet Cobra, the notorious space pirate who was previously forced into hiding due to facial surgery and memory erasure. Initially living an ordinary life, he regains his memories with the help of a dream machine. Alongside his android companion Lady Armaroid and his old ship Tortuga, he now faces both familiar and new enemies. The first story in the manga follows Cobra as he encounters the Royal sisters, whose bodies hold the key to a legendary treasure map.
Cobra was published in English in comic book format by VIZ Select Comics starting in 1990, but the publication was ended after the 12th issue. From December 3, 2014 to June 30, 2015, the title was again published, this time digitally by Creek & River Co., and comprised of 15 volumes that contained various chapters from both the original manga and sequel series.