The narrative recounts the tragic journey of an expedition to Antarctica that took place in September 1930. Dr. William Dyer, a researcher from Miskatonic University, led the team and documented their experiences in detail. Throughout his account, he emphasizes the importance of cautioning future explorers who may wish to return to the continent due to the dangers they encountered during their mission.
Kyouki no Sanmyaku nite was published English as H.P. Lovecraft's at the Mountains of Madness by Dark Horse as 2-in-1 omnibus volumes from June 26, 2019 to November 20, 2019.