Kyousuke Kousaka is a seventeen-year-old high school student who hasn't had a good relationship with his younger sister, Kirino, for years. She has always looked at him with disdain and ignored him. It seems like their relationship will continue this way forever. One day, Kyousuke finds a DVD case of the magical girl anime Hoshikuzu Witch Merle in his house's entranceway. Inside the case is an adult video game called Imouto to Koishiyo! (Love with Little Sister!). Kyousuke tries to find out who dropped the case by bringing up the topic at dinner, but he gets a negative reaction from his parents, especially his anti-otaku policeman father. That night, Kirino initiates a conversation with Kyousuke for perhaps the first time in years and shows him her collection of moe anime and lolicon bishoujo games that she has been keeping secret.
Ore no Imouto ga Konnani Kawaii Wake ga Nai was published in English by Dark Horse from September 4, 2012 to September 10, 2013. The series was also published in Spanish by Editorial Kamite from April 28, 2016 to September 28, 2016.