The 1920s in America were a time of peace and prosperity following the devastation of World War I. However, beneath this facade lurked a sinister force threatening to disrupt the tranquility. Sister Rosette Christopher, an exorcist from the Magdala Order, was tasked with combating these malevolent entities that caused chaos. Alongside her companion Chrno, she often ended up causing more harm than good. During one mission, they encountered a young girl named Azmaria, whose enchanting voice attracted unwanted attention from her own stepfather. Rosette and Chrno worked tirelessly to protect her, uncovering secrets about their own relationship in the process. There was more to these two individuals than met the eye.
Chrno Crusade was republished in Japan by Shonen Gahosha in 2010. The new edition featured brand-new book design and artwork, as well as logo changes, correcting the title spelling from "Chrno" to "Chrono," which had initially been a typo.The series was published by ADV Manga from June 8, 2004 to July 4, 2006. In addition, some of the series chapters were published in its anime and manga magazine Newtype USA.