Sena Kobayakawa is a small and timid individual who often becomes the target of bullies. He has recently enrolled at Deimon Private High School where he hopes to leave his past behind. During his first day at school, Sena refuses to act as an errand boy for a group of delinquents, which leads to a confrontation. In order to escape, Sena uses his speed, a skill he has developed through years of running from bullies.
Youichi Hiruma, the captain of the Deimon Devil Bats football team, witnesses Sena's "golden legs" in action and decides to recruit him as a running back despite Sena's desire to be the team manager. Sena is forced to wear the number 21 jersey and a special helmet to hide his identity as a player.
Sena becomes known as "Eyeshield 21," the teams closely guarded secret weapon. As he begins to enjoy football, Sena sets his sights on helping the Devil Bats reach the Christmas Bowl, the high school football championship.
Eyeshield 21 has sold more than 20 million copies in Japan and also has games produced by Konami and Nintendo.The series was published in English by VIZ Media under Shonen Jump Advanced imprint from April 5, 2005 to October 4, 2011 and has been licensed in France, Hong Kong, Indonesia, Italy, Taiwan, and South Korea.