Ninja Ryuukenden  

Ninja Gaiden, Ninja Gaiden OVA, Ninja Ryukenden, Tale of Ninja Ryuken, 忍者龍剣伝, Tale of Ninja Ryuuken, Ninja Ryu: The Dragon Sword Story

In New York City at night, Ryu encounters assassins who attack him. He defeats them and finds an ID card for the Friedman Company. The next day, it's announced that Dr. Ned Friedman has discovered a cancer cure. Sarah, a reporter, investigates with her friends Robert and Jeff after the press conference provides no information. While passing by Dr. Friedmans house one day, Ryu hears a young girl calling for help. When Sarah and her group investigate, they discover that Dr. Friedman is conducting experiments on live humans using biotechnology, which may be linked to the power of Evil Gods, whom Ryu had defeated in the past. However, when Irene, Ryus friend, is kidnapped, he must once again become a Dragon Ninja to save her from this new enemy.