In New York City at night, Ryu encounters assassins who attack him. He defeats them and finds an ID card for the Friedman Company. The next day, it's announced that Dr. Ned Friedman has discovered a cancer cure. Sarah, a reporter, investigates with her friends Robert and Jeff after the press conference provides no information. While passing by Dr. Friedmans house one day, Ryu hears a young girl calling for help. When Sarah and her group investigate, they discover that Dr. Friedman is conducting experiments on live humans using biotechnology, which may be linked to the power of Evil Gods, whom Ryu had defeated in the past. However, when Irene, Ryus friend, is kidnapped, he must once again become a Dragon Ninja to save her from this new enemy.
Robert was an American Special Forces soldier who helped Ryu during Ninja Gaiden II: The Dark Sword of Chaos by providing information about the Ashtar. After defeating Jacquio, he left the military to...
Ryu was born into the House of Hayabusa, which belongs to the Dragon Clan. In the past, Ryu engaged in an intense battle against Jaquio over the statues of the wicked demon. Despite the challenge, he ...
Ryu's girlfriend assists him in running his shop. In the Ninja Gaiden games, she was portrayed as a CIA agent. However, based on her behavior in the OAV, it appears that the authors have altered her c...
Professor Friedman is rumored to have invented the cure for cancer, but what is the truth behind his research?...
Sarah is a journalist who shares information with Robert and Jeffs detective agency. She is also a friend of Ryu and Irenes....