In a future world after an apocalypse that destroyed humanity and vampires, there is ongoing conflict between humans (Terran) and vampires (Methuselah), with two factions vying for power: the Vatican and the New Human Empire. Despite the violence and bloodshed, many people hope for a peaceful coexistence between the species. However, standing in the way is the Rosenkreuz Orden, a group of extremist vampires who manipulate both sides to fight against each other. To counter this threat, the Vatican's special operations unit "AX," led by Cardinal Caterina, must employ all available resources, including a vampire hunter who feeds on other vampires.
First four volumes of Trinity Blood: Rage Against the Moons were published in English by Tokyopop from April 10, 2007 to April 27, 2010.